Critical Environment Technologies
    Traditional Refrigerants

    R-422D

    R125/R134a/I…

    R-422D is an HFC refrigerant blend (R-125/R-134a/R-600a at 65.1/31.5/3.4%) designed as a drop-in retrofit replacement for R-22 in air conditioning systems. The isobutane (R-600a) content provides mineral oil compatibility, potentially eliminating lubricant changes during conversion. R-422D offers similar capacity to R-22 and has been widely adopted for residential and light commercial AC retrofit. With a GWP of 2,729, R-422D faces regulatory phase-down pressure. The zeotropic blend has significant temperature glide, requiring liquid charging to maintain proper composition. R-422D remains a popular choice where simple R-22 retrofit is needed without major system modifications.

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    Key Information

    Essential safety and exposure information for R-422D

    Health Effects

    Low toxicity classification. May cause cardiac sensitization. Contains trace flammable components.

    Common Sources

    • Residential and commercial AC
    • medium temperature refrigeration
    • heat pumps

    Exposure Limits

    WEEL
    1,000 ppm (8-hr TWA)
    No OSHA/NIOSH limit
    No OSHA/NIOSH limit
    Blend with R125/R134a
    Blend with R125/R134a

    Regulatory Status

    EPA Classification
    HFC blend (non-ODS)
    ASHRAE Safety Group
    A1 (low toxicity, non-flammable)
    GWP (AR5)
    2,729
    ODP
    0
    Temperature Glide
    Approximately 5°C
    AIM Act
    Subject to phase-down

    Detection Requirements

    Sensor Technology
    Infrared (NDIR)
    Detection Range
    0-1,000 ppm typical
    Response Time
    <30 seconds (T90)
    Calibration Frequency
    Annual recommended
    Temperature Glide
    Significant; charge as liquid only