R-143a
C₂H₃F₃R-143a (1,1,1-trifluoroethane, HFC-143a) is a hydrofluorocarbon primarily used as a component in refrigerant blends rather than as a standalone refrigerant. R-143a is a key component of R-404A (52%), R-507A (50%), and R-452A (30%), contributing to the thermodynamic properties of these low-temperature refrigerant blends. With a high GWP of 4,470, R-143a-containing blends are subject to stringent phase-down regulations. R-143a is classified as A2L due to mild flammability, though when blended with non-flammable components, the resulting mixtures are typically non-flammable. Understanding R-143a properties is important for technicians working with common commercial refrigeration blends and for leak detection system calibration.
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Key Information
Essential safety and exposure information for R-143a
Health Effects
May cause cardiac sensitization at high concentrations. Vapor can displace oxygen and cause asphyxiation in confined spaces.
Common Sources
- Component in R-404A
- R-507A blends
- commercial refrigeration systems
Exposure Limits
- WEEL
- 1,000 ppm (8-hr TWA)
- No OSHA/NIOSH limit
- No OSHA/NIOSH limit
- Simple asphyxiant hazard
- Simple asphyxiant hazard
Regulatory Status
- EPA Classification
- HFC (non-ODS)
- ASHRAE Safety Group
- A2L (low toxicity, mildly flammable)
- GWP (AR5)
- 4,470
- ODP
- 0
- Primary Use
- Component in R-404A, R-507A, R-452A blends
- AIM Act
- Blends containing R-143a subject to phase-down
Detection Requirements
- Sensor Technology
- Infrared (NDIR)
- Detection Range
- 0-1,000 ppm as component, 0-5,000 ppm in blends
- Response Time
- <30 seconds (T90)
- Calibration Frequency
- Annual recommended
- Blend Detection
- Usually detected as part of R-404A, R-507A, or R-452A
Related Applications
Industries and environments where R-143a detection is critical
Detection Solutions
Sensors and detectors for R-143a monitoring

cGas Detector VRF IR Refrigerant Transmitter
An aesthetic, non-dispersive infrared refrigerant gas detector for acute leak detection in modern energy-efficient buildings utilizing Variable Refrigerant Flow (VRF) HVAC systems.

cGas-SC Self-Contained Controller
A self contained controller with up to 3 gas channels, Plug & Play Smart Sensor Technology and configurable logic control and priority settings. Offers superior user customization and reliable gas detection performance for monitoring many gases.

cGas Detector IR Refrigerant Transmitter
Non-dispersive infrared refrigerant gas detector with accurate, low level leak detection, available with analog output or BACnet® or Modbus® output and Plug & Play Smart Sensor Technology.

FCS Multi Channel System Controllers
High performance controller with logic and priority settings for monitoring toxic, combustible and refrigerant gases with versatile control functionality. Available with Modbus® or BACnet® communication with BAS, supports 4-20 mA and Modbus® driven VFDs.