R-427A
R32/R125/R14…R-427A is an HFC refrigerant blend (R-32/R-125/R-143a/R-134a at 15/25/10/50%) developed as an alternative to R-22 for air conditioning and heat pump applications. The four-component blend offers performance characteristics similar to R-22 with reasonable environmental improvement. R-427A requires POE lubricant change during retrofit. With a GWP of 2,138, R-427A is subject to phase-down regulations but offers moderate improvement over some alternatives. The blend has found use in commercial AC systems and heat pumps where R-22 replacement is required. Temperature glide is moderate, requiring attention to charging procedures.
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Key Information
Essential safety and exposure information for R-427A
Health Effects
Low acute toxicity. May cause cardiac sensitization at high concentrations. Ensure adequate ventilation.
Common Sources
- Commercial HVAC
- refrigeration systems
- R-22 retrofits
Exposure Limits
- WEEL
- 1,000 ppm (8-hr TWA)
- No OSHA/NIOSH limit
- No OSHA/NIOSH limit
- Blend with R32/R125
- Blend with R32/R125
Regulatory Status
- EPA Classification
- HFC blend (non-ODS)
- ASHRAE Safety Group
- A1 (low toxicity, non-flammable)
- GWP (AR5)
- 2,138
- ODP
- 0
- AIM Act
- Subject to phase-down
- Use Case
- R-22 alternative for AC and heat pump applications
Detection Requirements
- Sensor Technology
- Infrared (NDIR)
- Detection Range
- 0-1,000 ppm typical
- Response Time
- <30 seconds (T90)
- Calibration Frequency
- Annual recommended
- Four-Component Blend
- May show varied response to different components
Detection Solutions
Sensors and detectors for R-427A monitoring

cGas Detector VRF IR Refrigerant Transmitter
An aesthetic, non-dispersive infrared refrigerant gas detector for acute leak detection in modern energy-efficient buildings utilizing Variable Refrigerant Flow (VRF) HVAC systems.

cGas-SC Self-Contained Controller
A self contained controller with up to 3 gas channels, Plug & Play Smart Sensor Technology and configurable logic control and priority settings. Offers superior user customization and reliable gas detection performance for monitoring many gases.

cGas Detector IR Refrigerant Transmitter
Non-dispersive infrared refrigerant gas detector with accurate, low level leak detection, available with analog output or BACnet® or Modbus® output and Plug & Play Smart Sensor Technology.

FCS Multi Channel System Controllers
High performance controller with logic and priority settings for monitoring toxic, combustible and refrigerant gases with versatile control functionality. Available with Modbus® or BACnet® communication with BAS, supports 4-20 mA and Modbus® driven VFDs.